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xxxx	1. Drug development typically requires:  A. 5-10 years  B. $100 million  C. 100 synthesized compounds  D. 5 human tested compounds  E. None of the above 2. A drug development process that precedes human trials is:  A. NDA  B. IND  C. Phase I testing  D. Phase III testing  E. Phase IV testing 3. Allergic rhinitis trial design include:  A. Outside abundant pollen season  B. Parallel group design  C. Cohort enrollment  D. Patients off usual medications  E. Patients on usual immunology 4. Which of the following are characteristic of old, first generation H-antihistamines?  A. Are not very well studied  B. May Cause dru mouth, uninary dysfunction  C. May impair psychomotor performance without causing sedation  D. May cause cardiac toxicity in overdose  E. All of the above 5. Which of the following are characteristic of new, second generation H--antihistamines?  A. Improved pharmacokinetics and pharmacodynamics compared to first generation H-antihistamines  B. Tachyphylaxis does not develop  C. No impairment of psychomotor performance or sedation relative to first generation H-antihistamines  D. Cardiac toxicity does not develop, even in overdose  E. All of the above 6. Which of the following characteristics are essential for next-generation H-antihistamines?  A. Potency in preclinical studies  B. Optimal pharmacokinetic and pharmacodynamic characteristics  C. No psychomotor performance impairment or sedation  D. No prolongation of the QT interval  E. All of the above 7. Which second generation has been linked to cardiac toxicity in man?  A. Loratadine  B. Cetirizine  C. Fexofenadine  D. Terfenadine 8. Adding pseudoephrine to a first generation antihistamine will prevent cognitive impairment in patients.  A. True  B. False